A victory against Italy will not guarantee that the team will progress to the final round of the Rugby Championship but it is certainly the most likely outcome.
The Eagles were beaten by the Springboks by a score of 13-6 in the opening round of fixtures.
They were also beaten by Italy in the semi-finals of the World Cup.
The first test of the tournament saw the Eagles go down 2-0 to Argentina in the first round and their last match was a 1-0 loss to the All Blacks in New Zealand.
Italy are ranked fifth and will host France in the final.
The Eagles lost their opening match to Argentina, but lost to France in their last game, losing to France by a margin of 23-14.
The Italians are ranked 11th in the world, and have a game in hand on the Eagles.
They face France on Saturday.